Jean‐Philippe Pin

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

This study shows that chronic activation of mGlu2 receptors with a nanobody accelerates amyloid formation and worsens memory deficits in Alzheimer's disease models.

The paper challenges the conventional view of GPCR internalization by showing multiple pathways regulate receptor internalization, with specific findings on the GLP-1R's mechanism.

This study identifies non-canonical internalization mechanisms for mGlu receptors, showing some require neither GRKs nor beta-arrestins for agonist-induced internalization.

This paper introduces a triple-labeling strategy for single molecule FRET to study conformational changes in GPCRs, revealing a previously unknown intermediate state.

This study shows that APP17, a peptide derived from APP, does not regulate GABAB receptor activity in heterologous cells or neurons, suggesting sAPP acts through other receptors.

This study shows that EGF-induced dimer formation activates EGFR, and that TK inhibitors affect EGFR internalization based on dimer conformation.

This study shows that chronic sodium bromide treatment reduces autistic-like behaviors in three mouse models of autism, with synergistic effects when combined with an mGlu4 receptor modulator.