Marta Cimadevila

This study shows that chronic activation of mGlu2 receptors with a nanobody accelerates amyloid formation and worsens memory deficits in Alzheimer's disease models.

The paper challenges the conventional view of GPCR internalization by showing multiple pathways regulate receptor internalization, with specific findings on the GLP-1R's mechanism.

This study identifies non-canonical internalization mechanisms for mGlu receptors, showing some require neither GRKs nor beta-arrestins for agonist-induced internalization.