A Foti

The paper shows lipid chlorination by MPO-derived hypochlorous acid enables NE release from granules, initiating NETosis.

This paper identifies RcrB as a detoxification system in uropathogenic Escherichia coli that protects against reactive chlorine species like HOCl by reducing extracellular HOCl and maintaining redox homeostasis.

This study shows SOD1 regulates ROS balance and antimicrobial activity in neutrophils by modulating O2- to H2O2 ratio and supporting MPO activity during NETosis and infection.

The paper identifies that tyrosine halogenation of α-defensins by hypohalous acids converts them into immunomodulatory mediators, revealing a novel oxidative mechanism in neutrophil function.