Michaël Nilges

The paper investigates the structural basis of endopilus assembly, stability, and functional specificity in bacterial type II secretion systems using comparative analysis of two pathogens.

This study identifies a structural trade-off in type IV pili that balances mechanical resilience and supramolecular adaptability using cryo-EM, simulations, and experimental validation.

The paper introduces NEF, a standard for NMR data exchange, and demonstrates its application in structure determination, metabolomics, and ligand screening.

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

InDeep predicts functional binding sites in proteins for drug design on PPIs, outperforming existing tools on both PPI and conventional targets.

This study determines the structural interactions between Streptococcus pyogenes M1 protein and human IgG using integrative structural biology, revealing conserved mechanisms to inhibit phagocytosis.

The paper introduces a Bayesian method to infer chromatin structure ensembles from population Hi-C data, accounting for cell-to-cell variability.

The paper introduces a graph-based method to build atomic protein models from cryo-EM density maps using residue co-evolution data to improve segmentation and sequence assignment.

The paper introduces a Bayesian scoring function to rank structural models using cryo-EM data and other information, validated on known complexes and implemented in an open-source platform.