Edna Cukierman

The paper shows cancer cells adapt along a proliferation-robustness axis in response to TME components, leading to pro-tumor phenotypes.

This study identifies an opioid-mediated signaling axis in pancreatic cancer that drives extracellular matrix remodeling and tumor aggressiveness, suggesting methylnaltrexone as a potential therapeutic.

This study shows sensory neurons inhibit breast cancer metastasis via CGRP-RAMP1-cAMP signaling, which suppresses invadopodia and ECM degradation.

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.

This study shows that pulsed low-dose-rate radiation combined with chemotherapy shifts pancreatic cancer-associated fibroblasts from tumor-promoting to tumor-suppressing, reducing desmoplasia and improving neoadjuvant therapy.