Ralph A. Francescone III

This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.

The paper identifies cell type-specific gene expression and immune cell associations in keloid tissue using bulk RNA-Seq and single sample gene set enrichment analysis.

This study shows sensory neurons inhibit breast cancer metastasis via CGRP-RAMP1-cAMP signaling, which suppresses invadopodia and ECM degradation.

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.

This study shows that pulsed low-dose-rate radiation combined with chemotherapy shifts pancreatic cancer-associated fibroblasts from tumor-promoting to tumor-suppressing, reducing desmoplasia and improving neoadjuvant therapy.