Thomas A. Edwards

This paper designs de novo bifunctional proteins for targeted protein degradation, demonstrating their ability to degrade BCL-xL in cells.

The paper demonstrates the use of coiled-coil scaffolds to enable targeted protein degradation by integrating target-binding and degradation motifs into single-polypeptide constructs.

This study identifies RNA-binding targets of the HOW(S) protein in Drosophila spermatogenesis using RIP-seq, revealing novel transcripts and motif preferences.

The paper reports the cryoEM structure of Hendra henipavirus nucleoprotein bound to RNA, revealing unique interactions in its multimeric assembly and insights into paramyxoviral nucleocapsid architecture.

This paper identifies two RAS-binding Affimer proteins that inhibit RAS function and reveal a novel druggable SII/3 pocket.