Séverine Leclerc

This study uses single-cell RNA-seq to analyze transcriptional changes in mouse hearts during perinatal development, identifying gene regulatory patterns and a cell type-independent imprinted gene signature.

This study shows that metabolic reprogramming in the neurovascular niche promotes regenerative angiogenesis in proliferative retinopathy by shifting metabolism from fatty acid oxidation to glycolysis.

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

This study shows that reducing Hdac2 in PV+ cells enhances fear memory extinction in adults by downregulating Acan, a perineuronal net component.

The paper develops a human intestinal organoid model with macrophages to study their role in development, finding that macrophages regulate metabolism and growth without affecting tissue architecture.