Gaël Cagnone

This study identifies SOX9 as a regulator of endothelial tip cell specification in brain and retinal vascularization, showing its role in promoting angiogenesis and revealing differences between developmental and injury-induced vascular responses.

This study identifies developmental senescence as a key mechanism driving hyaloid vessel regression in postnatal mice through single-cell RNA sequencing and genetic experiments.

This study shows that metabolic reprogramming in the neurovascular niche promotes regenerative angiogenesis in proliferative retinopathy by shifting metabolism from fatty acid oxidation to glycolysis.

This study identifies a novel angiogenic endothelial cluster driven by loss of ALK1 signaling in brain arteriovenous malformations (bAVMs) and shows that KIT inhibition prevents bAVM formation.

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

This study shows corticosteroids inhibit early pathological angiogenesis but hinder reparative vascular remodeling in retinopathy.

This study shows that metformin prevents cardiac dysfunction in a mouse model of adult congenital heart disease under metabolic stress.