Jean‐Sébastien Joyal

This study identifies developmental senescence as a key mechanism driving hyaloid vessel regression in postnatal mice through single-cell RNA sequencing and genetic experiments.

This study shows that metabolic reprogramming in the neurovascular niche promotes regenerative angiogenesis in proliferative retinopathy by shifting metabolism from fatty acid oxidation to glycolysis.

This study shows corticosteroids inhibit early pathological angiogenesis but hinder reparative vascular remodeling in retinopathy.

This study shows that inhibiting type I PRMTs with MS023 enhances muscle stem cell proliferation and regenerative potential while maintaining stemness.

The paper develops a human intestinal organoid model with macrophages to study their role in development, finding that macrophages regulate metabolism and growth without affecting tissue architecture.