Väinö Lithovius

This study shows that ghrelin and relamorelin reduce hypoglycaemia in humanised mice with KATPHI by enhancing glucose levels, especially when combined with octreotide.

This study improves the safety of stem cell-derived islets by enriching endocrine cells and reducing off-target cell types, enhancing long-term in vivo outcomes.

This study uses PET tracers to noninvasively monitor stem cell-derived islet graft volume and composition in mice, showing strong correlation with actual graft size and beta cell proportion.

This study shows that RFX6 haploinsufficiency impairs beta cell function, leading to reduced insulin secretion and increased diabetes risk.

This study shows that TYK2 is critical for β-cell development by regulating KRAS and IFN responses, suggesting TYK2 inhibition as a therapeutic target for type 1 diabetes.

This study generates and benchmarks functionally mature stem cell-derived islets, showing they closely resemble primary adult islets in transcriptional and functional properties.