Diego Balboa

Sodium tungstate enhances vascularization and improves survival of transplanted insulin-producing cells in diabetes models by upregulating VEGFA and promoting endothelial cell function.

The paper constructs a healthy human pancreas reference atlas to contextualize disease states and benchmark models.

This study identifies Scinderin as a regulator of Golgi actin remodeling that coordinates GLP-1 and insulin secretion, linking intracellular trafficking defects to glucose homeostasis and diabetes.

This study identifies a 94-bp deletion in the SLC16A1 promoter causing hyperinsulinism by increasing MCT1 expression and triggering inappropriate insulin secretion during physical activity.

This study shows that ghrelin and relamorelin reduce hypoglycaemia in humanised mice with KATPHI by enhancing glucose levels, especially when combined with octreotide.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

This study uses PET tracers to noninvasively monitor stem cell-derived islet graft volume and composition in mice, showing strong correlation with actual graft size and beta cell proportion.

The paper investigates the functional roles of 14 unique human mitochondrial ribosomal proteins in the small subunit, showing their essentiality in assembly and translation, with a redox-regulated role for mS37.

This study shows that RFX6 haploinsufficiency impairs beta cell function, leading to reduced insulin secretion and increased diabetes risk.

The paper identifies homozygous loss of function variants in ZNF808 as a cause of pancreatic agenesis in humans, showing its role in repressing transposable elements during pancreatic development.

This study shows that TYK2 is critical for β-cell development by regulating KRAS and IFN responses, suggesting TYK2 inhibition as a therapeutic target for type 1 diabetes.

This study generates and benchmarks functionally mature stem cell-derived islets, showing they closely resemble primary adult islets in transcriptional and functional properties.

This study identifies HASTER, a lncRNA that stabilizes HNF1A expression through cis-regulatory mechanisms, and shows its disruption leads to diabetes.

This study describes a protocol to generate hindbrain-like human brain organoids with mature, functional neurons and reports their response to Zika virus and anticonvulsants.