Jeffrey S. Mugridge

This study identifies conserved aromatic residues in FTO that recognize the mRNA 5' cap and enhance m6Am demethylation, providing structural insights into FTO's selectivity for m6Am over m6A.

This study identifies YhcC as an anaerobic alternative to MnmC for demodifying cmnm5s2U to nm5s2U in E. coli tRNA.

This study maps TRMT1's interactome using APEX2-based proximity labeling and DIA mass spectrometry, identifying proteins involved in RNA processing and redox biology.

This paper reports engineered FTO mutants that selectively demethylate m6A or m6Am RNA modifications, enabling study of their distinct biological roles.

This study reveals how ascorbate regulates FODD enzyme activity and substrate selectivity, providing structural insights into its role in RNA demethylation and broader biological oxidation reactions.

This paper introduces a modified mRNA cap analog, AvantCap, which improves mRNA purification and translational efficiency in vitro and in vivo.