Author

Zihong Chen

Ludwig Cancer ResearchORCID 0000-0002-1554-1649Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Zihong Chen1 paper · Texas Children's Hospital

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:metabolomics· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Joshua D. RabinowitziD· 2 shared Xincheng XuiD· 2 shared Akshada SawantiD· 1 shared Asael RoichmaniD· 1 shared Beianka TomlinsoniD· 1 shared Caroline BartmaniD· 1 shared Eileen WhiteiD· 1 shared Eric G. PameriD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Joshua D. RabinowitzORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedJun 20, 2025

Lack of consistent effect of dietary fiber on immune checkpoint blockade efficacy across diverse murine tumor models

Asael Roichman, Gabriela Reyes‐Castellanos, Ziqing Chen…·Joshua D. Rabinowitz

This study investigates the effect of dietary fiber on immune checkpoint blockade efficacy in murine tumor models and finds inconsistent results across different models.

14 citationstop 3%

mousemetabolomics

𝕏 PostBluesky

ImmunologyCell chemical biologyPeer-reviewedMay 1, 2024

One-carbon unit supplementation fuels tumor-infiltrating T cells and augments checkpoint blockade

Xincheng Xu, Zihong Chen, Caroline Bartman…·Joshua D. Rabinowitz

This study shows that supplementing one-carbon units enhances anti-PD-1 checkpoint blockade by supporting purine synthesis in tumor-infiltrating T cells, leading to increased durable tumor regression.

33 citationstop 5%

mousemetabolomics

𝕏 PostBluesky