Yue Feng

The paper shows how phages evade bacterial immune systems by using allelic variation and an anti-defense hotspot, revealing a similarity to a human protein.

The paper presents cryo-EM structures of type I and II Lamassu systems from different bacteria, revealing their architecture and mechanism of DNA cleavage.

This study shows CRISPR-Cas regulates diverse anti-phage systems via crlRNAs, balancing their expression to prevent autoimmunity and enhance anti-phage defense.

The paper develops AntiDefenseFinder to detect anti-defense systems in prokaryotes, phages, and MGEs, identifying 47,981 systems and revealing their distribution and evolutionary dynamics.

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

The paper identifies viral crlRNAs that suppress bacterial immunity by reprogramming Cas proteins and demonstrates their potential for mammalian genome editing.

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

This study investigates how AcrIF4 inhibits the type I-F CRISPR-Cas system by preventing Cas2/3 recruitment, not by blocking DNA binding.

This study reveals the structural and functional mechanisms of the type III-E CRISPR-Cas system by analyzing gRAMP-crRNA complexes and their interactions with target RNA.