Erin D. Huiting

The paper shows that CBASS effector CapV limits phage production without reducing cell viability in Pseudomonas aeruginosa by interfering with phage capsid assembly.

The paper identifies surface receptor masking and internal defenses as barriers to phage therapy in Pseudomonas aeruginosa clinical isolates and presents strategies to overcome these barriers through phage engineering.

The paper develops AntiDefenseFinder to detect anti-defense systems in prokaryotes, phages, and MGEs, identifying 47,981 systems and revealing their distribution and evolutionary dynamics.

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

The paper identifies two highly conserved core defense hotspots in Pseudomonas aeruginosa containing numerous anti-phage systems, including a newly discovered system called Shango.