Xavier Le Guezennec

The paper shows that GALA, a process relocating GALNTs to the ER, enables co-translational O-glycosylation in pancreatic cancer, expanding the O-glycoproteome and promoting tumor growth.

This study identifies ER O-glycosylation by GALNTs in synovial fibroblasts as a driver of cartilage degradation in arthritis, with Calnexin as a potential therapeutic target.

This study identifies 2β1 integrin and MAP3K1/p38 signaling as regulators of ECM internalization, which promotes cancer cell migration and invasion in breast and pancreatic cancers.