Thorsten B. Blum

This study evaluates the impact of X-ray radiation doses on cryo-preserved biological samples, showing that high doses do not prevent subsequent cryo-EM analysis for intermediate to high-resolution structural insights.

The paper reports the cryo-EM structure of connexin-36 bound to mefloquine, revealing how small molecules inhibit gap junction channels by partially occluding the pore and altering electrostatics.