Author
National Institutes of HealthORCID 0000-0002-1620-3027Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Róli Rodrigues Simões, Scheila Kraus, Jintao Zhang…·Yuqing Q. Cao
This study identifies multiple pathways suppressing stress-induced chronic pain and shows low-dose IL-2 effectively resolves sensitization without relying on opioid or GABA signaling.
M. Bram Kuijer, Camryn J. Fulton, Talia L. Albert…·Bryan L. Roth
The paper examines how sodium ions differentially modulate agonist-induced conformational changes and signaling at μ and κ opioid receptors, revealing opposing effects between the two receptor types.
Evan S. O’Brien, Vipin Ashok Rangari, Amal El Daibani…·Brian K. Kobilka
This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.
Kerri D. Pryce, Hye Jin Kang, Farhana Sakloth…·Marta Filizola
The paper characterizes two MOR PAMs that enhance opioid antinociception without increasing adverse effects in mouse models.
Xi-Ping Huang, Tao Che, Thomas Mangano…·Bryan L Roth
This study investigates the pharmacological profiles of W-18 and W-15, finding no significant opioid activity or other psychoactive drug target interactions.