Author

Patryk Ludzia

University of OxfordORCID 0000-0002-1678-6875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Bungo AkiyoshiiD· 3 shared Midori IshiiiD· 3 shared Christina RedfieldiD· 2 shared Aleksandra Ciszek· 1 shared Christopher W. WoodiD· 1 shared Christos SpanosiD· 1 shared Daniel BallmeriD· 1 shared Eelco C. TromeriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

Bungo AkiyoshiORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 18, 2026

The centromere localization domain of kinetoplastid kinetochore protein KKT2 recognizes the free N-terminus of histone H3

Aleksandra Ciszek, Patryk Ludzia, Gabriele Marcianò…·Bungo Akiyoshi

This study shows that the KKT2 CL domain binds histone H3 N-terminus and that methylation of this region disrupts binding, suggesting a mechanism for kinetochore assembly in kinetoplastids.

DOI 10.64898/2026.08.13.744621

proteomicsexperimental assay

𝕏 PostBluesky

Cell BiologyStructurePeer-reviewedNov 22, 2024

The kinetoplastid kinetochore protein KKT23 acetyltransferase is a structural homolog of GCN5 that acetylates the histone H2A C-terminal tail

Patryk Ludzia, Midori Ishii, Gauri Deák…·Bungo Akiyoshi

This study determines the structure and function of KKT23, a kinetochore acetyltransferase in trypanosomes, showing it acetylates histone H2A and interacts with KKT22.

7 citations

humanmouse

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Cell BiologyOpen BiologyPeer-reviewedJun 1, 2024

Kinetoplastid kinetochore proteins KKT14-KKT15 are divergent Bub1/BubR1-Bub3 proteins

Daniel Ballmer, William Carter, Jolien J. E. van Hooff…·Bungo Akiyoshi

This study identifies KKT14-KKT15 in kinetoplastids as divergent orthologs of Bub1/BubR1-Bub3, suggesting a unique mechanism for chromosome segregation fidelity in trypanosomes.

13 citations

protein structureexperimental assay

𝕏 PostBluesky