Author

Jana Helsen

Stanford MedicineORCID 0000-0002-2637-7047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:yeast· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Gautam DeyiD· 2 shared Gavin J. SherlockiD· 2 shared Kausthubh RamachandraniD· 1 shared Md Hashim RezaiD· 1 shared Ricardo CarvalhoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersEvolutionary Biology

Gautam DeyORCID

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2 papers

Recent·Most cited

Evolutionary BiologyNaturePeer-reviewedNov 26, 2025

Centromeres evolve progressively through selection at the kinetochore interface

Jana Helsen, Kausthubh Ramachandran, Gavin J. Sherlock, Gautam Dey

The paper investigates how new centromeres evolve and become fixed in budding yeast by analyzing 138 species and 2,500 isolates, showing that kinetochore interface constraints influence centromere evolution.

12 citationstop 3%

yeaststatistical model

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Cell BiologyNature Cell BiologyPeer-reviewedAug 8, 2024

Spindle architecture constrains karyotype in budding yeast

Jana Helsen, Md Hashim Reza, Ricardo Carvalho…·Gautam Dey

The paper shows that spindle architecture limits karyotype evolution in budding yeast by demonstrating that chromosome fusions are tolerated until a critical centromere number is reached.

4 citations

yeastexperimental assay

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