Kevin H.-C. Wei

The paper investigates non-Mendelian transmission of recombinants in female meiosis, showing that chromatids with crossovers have a transmission advantage under nutrient stress in Drosophila.

The paper studies a young Y chromosome in Drosophila albomicans that recombines with the X chromosome before recombination shutdown, maintaining long-range linkage without inversions.

DemuxHMM improves demultiplexing for large-scale single-cell datasets by modeling recombination patterns, enhancing scalability and accuracy in developmental studies.

This study examines the evolutionary dynamics of the synaptonemal complex in Drosophila, revealing recurrent positive selection and diversification of SC genes through duplications and regulatory changes.

The paper investigates how polymorphic transposable elements (TEs) influence meiotic recombination rates in Drosophila by analyzing crossover frequencies in strains with distinct TE profiles.

The paper presents 183 new genome assemblies for 179 drosophilid species using single-fly long-read sequencing, improving phylogenomic coverage and enabling a well-resolved multi-locus phylogeny.

The paper tests a candidate meiotic drive locus in Drosophila melanogaster using individual progeny genotyping, finding a small deviation from Mendelian segregation opposite to initial pool sequencing results.

The paper maps H3K9me3-dependent heterochromatin formation in Drosophila miranda embryos, showing early nucleation at transposable elements and piRNA-mediated silencing.

This paper introduces a method to estimate chromosome-wide recombination rates using marker selected pools and validates it with simulations and empirical data.

The paper assembles the Drosophila miranda Y chromosome using long reads and chromatin conformation capture, revealing its expansion through repetitive sequences.

The paper develops a pooled sequencing method to detect meiotic drivers in Drosophila and identifies a candidate driver in a centromere-linked region with an 8% increased transmission frequency.