Ching-Ho Chang

A rapidly evolving essential protamine suppresses sex-chromosome meiotic drive in Drosophila.

The paper investigates whether Cenp-C genes duplicated alongside Cid genes in the montium group of Drosophila, finding that most species retain only one Cenp-C gene despite multiple syntenic loci.

The paper studies a young Y chromosome in Drosophila albomicans that recombines with the X chromosome before recombination shutdown, maintaining long-range linkage without inversions.

The paper investigates the role of Rsp-derived small RNAs in the Segregation Distorter drive system in Drosophila melanogaster, showing haplotype-specific variations in their contribution to drive strength.

The paper identifies suppressors that limit the spread of the selfish Segregation Distorter in Drosophila melanogaster by analyzing genetic variation across 90 strains.

This study examines the evolutionary dynamics of the synaptonemal complex in Drosophila, revealing recurrent positive selection and diversification of SC genes through duplications and regulatory changes.

The paper investigates the evolutionary dynamics of genes involved in heterochromatin functions in Drosophila, finding they evolve faster than Polycomb-based repressive chromatin genes.

The paper studies Y chromosome evolution in Drosophila species, finding rapid divergence, new gene families under positive selection, and biased repair mechanisms.

The paper investigates spermiogenic defects in Drosophila melanogaster SD/SD+ males and links them to Rsp satellite DNA copy number, showing how high Rsp levels trigger sperm elimination.

The paper generates high-quality genomes for Drosophila simulans species complex to study repetitive DNA evolution and structural divergence between species.

The paper identifies the sequence composition of Drosophila melanogaster centromeres, showing they are composed of retroelement islands flanked by satellite repeats, with G2/Jockey-3 being the most enriched retroelement.

The paper develops a method to assemble heterochromatic regions of the Drosophila melanogaster Y chromosome, revealing its sequence organization and evolutionary dynamics.

The paper generates genomes for three bioluminescent beetles to study the genetic basis of bioluminescence and finds at least two independent evolutionary origins of the trait.