Jérémy Dufloo

The paper identifies entry inhibitors against emerging viruses using a phylogenetic framework, finding drugs with broad antiviral activity across related viral RBPs.

This study shows that sialic acids restrict entry of non-influenza orthomyxoviruses, unlike influenza viruses, and identifies mutations that can overcome this restriction.

This study identifies dipeptidase 1 as the receptor for PHEV, showing it does not require sialic acid and reveals structural versatility in receptor binding.

This study identifies six novel bat coronaviruses in Spain, three of which are potentially new species, and finds one can use human ACE2 receptor, indicating zoonotic potential.

This study uses experimental evolution to identify mutations in the SADS-CoV spike protein that enhance its ability to infect human cells, potentially increasing its zoonotic potential.

The paper experimentally tests the ability of viral receptor-binding proteins from 100+ enveloped RNA viruses to enter human cells, finding that most can do so, with variation among families and host factors playing a role.

This study shows that temperature affects SARS-CoV-2 spike fusogenicity and evolution, with higher temperatures increasing fusion and specific mutations showing temperature-dependent effects.

This study compares complement-mediated immunity differences between humans and rhesus macaques, finding sex-based variations in humans and species-specific differences in complement activity.

This study shows how SARS-CoV-2 spike protein adapts to different human cell types through mutations that affect entry efficiency and receptor affinity.