Vladimir V. Svetlov

This study determines the cryo-EM structure of HP1 bound to an H2A.Z nucleosome, revealing two binding sites and their roles in transcriptional repression and chromatin compaction.

The paper investigates how phosphorylated nucleotides like remdesivir triphosphate and ppGpp activate SARS-CoV-2 RdRp through allosteric mechanisms involving the NiRAN domain and Nsp7/8 subunits.

The paper investigates how cross-linker length and molecular motions affect XL-MS depth and distance restraints for protein-protein docking.

The paper describes an automated workflow for discovering and simulating protein-protein complexes using in vivo chemical cross-linking and mass spectrometry.