Dongyan Tan

This study investigates how MacroH2A (mH2A) contributes to gene repression by stabilizing nucleosome dynamics and inhibiting chromatin remodelers.

This paper introduces a graphene-based affinity cryo-EM grid (GFD-A) for capturing endogenous protein complexes, achieving resolutions of 2.71 Å for tagged proteins and 3.0–3.9 Å for endogenous RNase MRP and RNase P.

This study determines the cryo-EM structure of HP1 bound to an H2A.Z nucleosome, revealing two binding sites and their roles in transcriptional repression and chromatin compaction.