Author

Julien Lagarde

Centre National de la Recherche ScientifiqueORCID 0000-0002-2018-261XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Marie SaraziniD· 4 shared Michel BottlaenderiD· 3 shared Fanny EysertiD· 2 shared Frédéric ChecleriD· 2 shared Guillaume DorothéeiD· 2 shared Mounia ChamiiD· 2 shared Sandra Lacas‐GervaisiD· 2 shared Allyson Hinks· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Marie SarazinORCID

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4 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintOct 7, 2026

Somatic instability of the C9orf72 repeat expansion in blood differs between patients with amyotrophic lateral sclerosis or frontotemporal dementia.

Mathieu Barbier, Mounir Ichalalen, Maria del Mar Amador…·Isabelle Le Ber

This study uses optical genome mapping to analyze C9orf72 repeat expansion instability in blood from ALS and FTD patients, finding age-dependent differences in repeat size dynamics between conditions.

DOI 10.64898/2026.10.06.26364580

humanDNA methylation

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NeurosciencebioRxivPreprintMay 12, 2026

Experimental and natural peripheral HSV-1 infection: Neurotropism and impact on Alzheimer's disease-related molecular markers

Axel Legrand, Susana Boluda, Marina S. Boukhvalova…·Benoı̂t Delatour

This study investigates the role of HSV-1 infection in Alzheimer's disease by analyzing its impact on Aβ and Tau pathologies in animal models, postmortem brain samples, and AD patients.

DOI 10.64898/2026.05.07.723559

humanspatial transcriptomics

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NeurosciencebioRxivPreprintJan 8, 2025

Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions

Fanny Eysert, Véronique Legros, Anne-Sophie Gay…·Mounia Chami

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.

DOI 10.1101/2025.01.08.631851

humanproteomics

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Cell BiologyActa Neuropathologica CommunicationsPeer-reviewedJun 8, 2024

Mitochondria alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks

Fanny Eysert, Paula Fernanda Kinoshita, Julien Lagarde…·Mounia Chami

The paper examines mitochondrial alterations in fibroblasts from Alzheimer's disease patients and links them to clinical hallmarks and cognitive decline.

15 citations

humanexperimental assay

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