Andrew D. Beale

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

The paper introduces iClima, a ratiometric genetically encoded sensor for imaging GABAergic chloride currents, showing it can detect Cl- transients in vitro and in vivo with improved photostability and pH independence.

The paper shows that glucocorticoid receptor signaling resets circadian rhythms through post-transcriptional mechanisms, not transcriptional activation.

The paper shows that circadian rhythms in intracellular potassium levels regulate the cell cycle in algae and mammalian cells.

This study demonstrates circadian rhythms in human brain cells and organoids, showing they are temperature-compensated and modulated by drugs and cortisol, with implications for chronobiology and brain health.

The paper identifies a conserved cell-intrinsic signal inversion that enables the transition from nocturnality to diurnality, with mTOR signaling as a central mediator.

The paper shows yeast cells use temporal metabolic oscillations to coordinate protein synthesis with energy availability, storing resources and releasing them in bursts to maintain homeostasis.