Andrei Mihut

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

The paper shows that glucocorticoid receptor signaling resets circadian rhythms through post-transcriptional mechanisms, not transcriptional activation.

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

This study demonstrates circadian rhythms in human brain cells and organoids, showing they are temperature-compensated and modulated by drugs and cortisol, with implications for chronobiology and brain health.

The paper identifies a conserved cell-intrinsic signal inversion that enables the transition from nocturnality to diurnality, with mTOR signaling as a central mediator.