Cancer BiologybioRxivPreprint
CCR8⁺ regulatory T cell depletion overcomes immune checkpoint blockade resistance in BRCA2-deficient prostate cancer
Kimberly A. Rickman, Irena Q. Sun, Ramya Parameswaran…·Alan Ashworth
DOI 10.64898/2026.11.11.765808
Author
Hanbing Song
University of California, San FranciscoORCID 0000-0002-2164-8813Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2020-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 32 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- GenomicsbioRxivPreprint
A single-cell and spatial atlas of prostate cancer reveals the combinatorial nature of gene modules underlying lineage plasticity and metastasis
Hanbing Song, Junxiang Xu, Keila Velázquez-Arcelay…·Franklin W. Huang
The paper constructs a single-cell and spatial atlas of prostate cancer to reveal gene modules driving lineage plasticity and metastasis, identifying new biological insights and a transformer-based model for cell-state classification.
- Cancer BiologyNature CommunicationsPeer-reviewed
Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state
Heiko Yang, Hanbing Song, Elizabeth Yip…·Franklin W. Huang
Single cell RNA sequencing of bladder cancer subtypes identified a CA125+ cell state linked to aggressive features and TM4SF1 as a therapeutic target.
- Cancer BiologyCell ReportsPeer-reviewed
RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4
Hannah N. W. Weinstein, Kevin Hu, Lisa Fish…·Franklin W. Huang
This study identifies RPL22 as a tumor suppressor in MSI-H cancers that regulates MDM4 splicing and reveals its role in oncogenic pathways.
30 citationstop 3% - GenomicsbioRxivPreprint
Single cell transcriptional profiling of benign prostatic hyperplasia reveals a progenitor-like luminal epithelial cell state within an inflammatory microenvironment
Rei Unno, Jon Akutagawa, Hanbing Song…·Thomas Chi
This study uses single-cell RNA-seq to identify a luminal progenitor cell state in BPH linked to inflammation and MIF interactions.
- GenomicseLifePeer-reviewed
Comprehensive characterization of the transcriptional response to COVID-19 in multiple organs reveals shared signatures across tissues
Alejandro A. Granados, Simon Bucher, Aditi Agrawal…·Bruce Wang
The paper characterizes the transcriptional response to COVID-19 across multiple organs using single-nuclei RNA sequencing, identifying shared transcriptional signatures in endothelial cells and macrophages.
- GenomicsEuropean UrologyPeer-reviewed
Expression of ACE2, the SARS-CoV-2 receptor, and TMPRSS2 in prostate epithelial cells
Hanbing Song, Bobak Seddighzadeh, Matthew R. Cooperberg, Franklin W. Huang
The paper examines sex differences in ACE2 and TMPRSS2 expression in prostate and lung epithelial cells, finding higher ACE2 expression in male lung type II pneumocytes and co-expression in prostate club cells.