Catherine C.Y. Chang

This study shows that inhibiting ACAT1/SOAT1 in APOE4 mice reduces brain inflammation by lowering cholesterol esters and TLR4 levels.

This study evaluates a nanoparticle-formulated ACAT1 inhibitor in mice, showing brain delivery and reduced AD pathology without toxicity.

This study shows that blocking ACAT1 in microglia reduces LPS-induced neuroinflammation by altering TLR4 trafficking and degradation.

The paper shows that Acat1 gene knockout improves cholesterol levels and extends lifespan in mutant Npc1 mice by correcting cholesterol mislocalization.