R. Andrés Floto

This paper introduces a new spectral single-molecule microscopy technique using spatially patterned detectors, achieving spectral and positional resolution without complex optical components.

This study uses spatial transcriptomics to map Pseudomonas aeruginosa niches in lung tissue from CF and COPD patients, revealing distinct bacterial states and host interactions linked to infection persistence.

This study shows that Pseudomonas aeruginosa uses motility to enhance phagocytosis by macrophages, while reduced motility in chronic infections helps evade engulfment, and T3SS activity enables acute immune evasion.

This study introduces ASCT to assess bacterial killing in real-time and links drug tolerance to clinical outcomes in mycobacterial infections.

The paper analyzes defence system interactions in Pseudomonas aeruginosa genomes to understand their role in shaping accessory genome dynamics and ecological patterns.

This study uses mutational spectra to infer influenza virus transmission routes and adaptive mutations enabling sustained respiratory transmission.

This study shows verapamil reduces inflammation in cystic fibrosis by normalizing epithelial calcium signaling and oxidative stress in zebrafish and human cells.

Trained on over 1.3 million bacterial genomes represented as ordered protein sequences, the transformer foundation model Bacformer predicts protein interactions, operons, essentiality, and phenotypes while generating trait-conditioned synthetic proteomes.

This study shows curcumin improves inflammation and tissue damage in cystic fibrosis by restoring NRF2 activity in zebrafish and patient-derived airway organoids.

A uniformly processed set of 2,440,377 bacterial and archaeal genomes with search tools and annotations, plus an AI-mined peptide set yielding ATB20, active in a mouse skin infection model.

This study introduces GeneBac, a deep learning model that predicts antibiotic resistance from bacterial genomic sequences, showing accurate MIC prediction and variant effect assessment.

The paper introduces MutTui, a tool to calculate and compare mutational spectra of DNA and RNA pathogens using multiple sequence data types.

Panaroo's graph-based pangenome clustering uses gene adjacency across genomes to correct annotation errors, shrinking spurious accessory genomes and enlarging core genomes in simulated and real bacteria.