Kathleen M. McAndrews

This study develops a microfluidic device to enrich pancreatic cancer-derived extracellular vesicles based on charge, linking KRAS status to EV secretion and surface charge.

This study investigates how CDK8 remodels the tumor microenvironment to resist KRASG12D inhibition in PDAC, showing that targeting CDK8 can overcome resistance and improve survival.

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

This paper introduces a rapid and high-yield method for isolating extracellular vesicles with high purity, demonstrating its effectiveness across multiple sources and applications.

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

The paper uses cryo-TEM and a segmentation model to analyze EV architecture, finding consistent structural heterogeneity across different sources and purification methods.