Author

Ryan Apathy

University of California, San FranciscoORCID 0000-0002-2203-7117Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexander MarsoniD· 3 shared Theodore L. RothiD· 3 shared Daniel Goodman· 2 shared David N. NguyeniD· 2 shared Eric ShifrutiD· 2 shared Jeffrey A. BluestoneiD· 2 shared Anna Truong· 1 shared Benjamin E. SmithiD· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Alexander MarsonORCID

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Author profile →

3 papers

Recent·Most cited

Molecular BiologyeLifePeer-reviewedDec 31, 2021

Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

Dasmanthie De Silva, Lucas Ferguson, Grant H. Chin…·Jamie H. D. Cate

This study identifies eIF3's role in regulating TCR translation via 3-UTR binding, enhancing CAR-T cell efficacy in vitro.

34 citations

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintApr 12, 2019

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

Theodore L. Roth, P. Jonathan Li, Jasper F. Nies…·Alexander Marson

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.

DOI 10.1101/604561

humanCRISPR screen

𝕏 PostBluesky

BioengineeringbioRxivPreprintMar 28, 2019

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances genome targeting in diverse human immune cell types

David N. Nguyen, Theodore L. Roth, Jonathan Li…·Alexander Marson

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.

DOI 10.1101/591719

humanCRISPR screen

𝕏 PostBluesky