Author

Jeffrey A. Bluestone

Gladstone InstitutesORCID 0000-0001-8793-7848Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Alexander MarsoniD· 3 shared Theodore L. RothiD· 3 shared Daniel Goodman· 2 shared David N. NguyeniD· 2 shared Eric ShifrutiD· 2 shared Ryan ApathyiD· 2 shared Alice Y. K. ChaniD· 1 shared Alyssa C. IndartiD· 1 shared

Activity by Year

2016-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

Alexander MarsonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologyThe Journal of Experimental MedicinePeer-reviewedJul 8, 2026

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy

Alyssa C. Indart, Huiyun Lyu, Vinh Q. Nguyen…·Qizhi Tang

This study develops a receptor-tethered orthogonal IL-2 system to enhance Treg persistence and efficacy in autoimmune diabetes, showing improved survival and therapeutic outcomes.

4 citationstop 2%

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintApr 12, 2019

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

Theodore L. Roth, P. Jonathan Li, Jasper F. Nies…·Alexander Marson

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.

DOI 10.1101/604561

humanCRISPR screen

𝕏 PostBluesky

BioengineeringbioRxivPreprintMar 28, 2019

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances genome targeting in diverse human immune cell types

David N. Nguyen, Theodore L. Roth, Jonathan Li…·Alexander Marson

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.

DOI 10.1101/591719

humanCRISPR screen

𝕏 PostBluesky

GeneticsbioRxivPreprintDec 5, 2016

Discovery of an autoimmunity-associated IL2RA enhancer by unbiased targeting of transcriptional activation

Dimitre R. Simeonov, Benjamin G. Gowen, Mandy Y. Boontanrart…·Alexander Marson

The paper identifies an IL2RA enhancer associated with autoimmunity using CRISPRa and shows it affects gene activation timing without blocking expression.

4 citations

humanmouse

𝕏 PostBluesky