Cédric Peirs

This study identifies a previously dormant neuronal circuit in the spinal dorsal horn that becomes active in neuropathic pain, leading to mechanical allodynia.

The paper identifies functionally distinct subtypes within Grpr+ neurons in the dorsal horn that mediate itch and mechanical allodynia, demonstrating the utility of genomic enhancer-based strategies for modality-specific targeting.

This study shows nerve injury shifts spinal circuit recruitment from inhibitory to excitatory parvalbumin interneurons, causing mechanical allodynia.

This study identifies spinal oxytocin circuits as a conserved mechanism through which affiliative touch reduces pain and enhances well-being in mice and humans.

Senolytic drugs reduce low back pain by eliminating senescent cells and decreasing inflammatory factors in the intervertebral disc and spinal cord.

This study shows that regulatory T cells modulate basal somatic sensitivity in mice through enkephalin production, with Penk expression regulated by TNF receptor family and Batf.