Michael Rother

This study engineers Methanosarcina acetivorans to produce bisabolene from one-carbon compounds, achieving 10.6 mg/liter, demonstrating its potential for isoprenoid bioproduction.

This study enables formate-dependent methanogenesis in Methanosarcina acetivorans through metabolic engineering and adaptive evolution, expanding its substrate utilization capabilities.

This paper investigates why Methanosarcina acetivorans cannot use glucose for methanogenesis despite having glycolytic and gluconeogenic pathways, finding that glucose causes growth inhibition and carbohydrate accumulation.