Amedeo Caflisch

This study shows that the NTD of TDP-43 binds UG-rich RNA on monomers, while oligomerization is essential for repressing cryptic exons.

The paper designs cyclic peptides to inhibit prion conversion in vitro, showing one peptide significantly reduces PrPSc levels by stabilizing PrPc structure.

Minimal residue sets were mapped that let blind grape and soybean FLS2 receptors recognize evading flg22 peptides, giving two design principles and an engineered GmFLS2 variant with stronger flg22Rso responses.

This study reveals the catalytic mechanism of METTL3-14 by identifying two adenosine binding conformations, the methyl transfer transition state, and the roles of key residues in catalysis.

This study identifies K27 as a critical residue for GDL toxicity and prion-related neurodegeneration using ex vivo reverse genetics in PrPC-deficient slices.

This study examines firing irregularities in the medial temporal lobe during a working memory task and finds that burst activity and irregular firing patterns are related to response times and memory load decoding.

This study uses molecular dynamics simulations to examine how curcumin degradation products interact with Aβ42 dimers, showing π-π stacking interactions and structural changes.

The paper identifies sequence preferences for de novo DNA methylation by DNMT3A and DNMT3B in mouse stem cells, showing structural basis for context-specific methylation.