Alexis M. Gautreau

This study identifies BRK1 and CCDC53 as key subunits in WAVE and WASH complex assembly, showing their interaction with HSBP1 and their role in regulating actin dynamics and cell migration.

This study shows vinculin organizes long-range transcellular actin fibres (TAFs) that coordinate collective migration in MCF10A cells during unjamming.

This study identifies PKN2 and MOB4 as regulators of collective cell migration, showing PKN2 stabilizes junctions and MOB4 controls migration orientation through YAP1.

This study shows that vinculin's interaction with Arp2/3 inhibits branched actin assembly, affecting cell migration and cell cycle progression in mammary epithelial cells.

The paper shows that inactivating three negative regulators of cortical branched actin enhances migration persistence in human and zebrafish cells, with vimentin down-regulation contributing to the stable maintenance of this phenotype.