Cell BiologyMolecular Biology of the CellPeer-reviewed
Differential effects of aneuploidy on growth and differentiation in human intestinal stem cells
Blake A. Johnson, Albert Z. Liu, Tianhao Bi…·Rong Li
This study investigates how different types of aneuploidy affect growth and differentiation in human intestinal stem cells, finding that complex aneuploidy triggers p53 activation and cell-cycle arrest, while simple aneuploidy allows continued proliferation and impaired differentiation.