Blake A. Johnson

This study shows that aneuploidy alters nucleolar morphology by changing the number of nucleolar organizing regions (NORs), leading to enlarged nucleoli in cancer cells.

This study shows that p53 prevents genome instability by halting cell division under hypo-osmotic stress through G1 arrest and downstream gene activation.

The paper identifies PRR14L as a gene affecting mitotic fidelity and sensitivity to MPS1 inhibition through a CRISPR/Cas9 screen and proximity labeling.

This paper introduces a pipeline for 3D organoid analysis using multilevel segmentation and cellular topology to quantify morphology and topology changes under various stress conditions.

This study investigates how different types of aneuploidy affect growth and differentiation in human intestinal stem cells, finding that complex aneuploidy triggers p53 activation and cell-cycle arrest, while simple aneuploidy allows continued proliferation and impaired differentiation.

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.