Tatianna Larman

This study shows that aneuploidy alters nucleolar morphology by changing the number of nucleolar organizing regions (NORs), leading to enlarged nucleoli in cancer cells.

This study investigates how different types of aneuploidy affect growth and differentiation in human intestinal stem cells, finding that complex aneuploidy triggers p53 activation and cell-cycle arrest, while simple aneuploidy allows continued proliferation and impaired differentiation.

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.