BioengineeringMolecular CellPeer-reviewed
Protein language models-assisted engineering of Uracil-N glycosylase enables programmable T-to-G and T-to-C base editing
Yan He, Xibin Zhou, Chong Hwan Chang…·Xing Chang
This study uses protein language models to engineer a uracil-N-glycosylase variant for programmable T-to-G and T-to-C base editing, achieving high success rates in correcting genetic mutations in mice.
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