Sabine Fuhrmann

The paper compares two Rax-Cre transgenic drivers in mice to evaluate their Cre activity in the embryonic eye and extra-ocular tissues.

This study develops a diet gel-based oral drug delivery system for controlled dosing of PLX5622 and Tamoxifen in mice, achieving high microglia depletion and inducible Cre recombination.

This study investigates the sequence of pathological events caused by Dicer loss in Muller glia, showing cone dysfunction precedes rod degeneration and retinal remodeling.

This study shows that loss of Cdc42 in mice causes defects in optic cup morphogenesis, leading to microphthalmia and coloboma due to impaired cell polarity, junctions, and proliferation.

This study shows that Tbx3 loss in mice causes retinal angiogenesis defects similar to human ROP and FEVR, highlighting its role in eye development.

This study shows that Porcn is essential for optic vesicle growth and morphogenesis in mammals by regulating proliferation and survival, and its loss leads to microphthalmia in FDH patients.

This study identifies Nf2's role in regulating proliferation and tissue alignment during optic fissure closure in the mouse eye, showing that its loss causes coloboma due to RPE hyperproliferation and cytoskeletal disorganization.