Edward M. Levine

This study investigates the role of Sonic Hedgehog signaling in retinal development, revealing new functions in optic nerve head identity, nasal-temporal polarity, and coordination of neurogenesis.

This study identifies electrical stimulation and p27Kip1 inactivation as a combined strategy to enhance proliferation and neurogenesis of Mueller glia in a 3D culture model.

This study develops a diet gel-based oral drug delivery system for controlled dosing of PLX5622 and Tamoxifen in mice, achieving high microglia depletion and inducible Cre recombination.

This paper introduces a submergence-free electroporation method for ex vivo retinal tissue cultured at the air-liquid interface, enabling efficient gene delivery and revealing electrical stimulus-induced cell cycle reentry in retinal cells.

This study characterizes a LacZ knock-in/knock-out allele at the Vsx2 locus in mice, revealing its role in retinal development and identifying potential incomplete knock-out effects.

This study shows Lhx2 modulates Sonic Hedgehog signaling in retinal progenitors through direct and indirect regulation of pathway components, establishing competence for signaling during early neurogenesis.

This study shows that Arap1 in retinal pigment epithelium (RPE) is essential for photoreceptor survival through its role in phagocytosis, as Arap1 deficiency leads to photoreceptor degeneration.

The paper compares the spatial expression of Sonic Hedgehog and pathway components in the embryonic mouse head to understand context-dependent feedback regulation.