Qi Zhang

This paper develops a DAG-mimetic fluorescent probe, DONDI-5, to visualize diacylglycerol dynamics at lipid droplets and shows DAGs can be stored there without converting to triacylglycerols.

This study shows that OGA inhibitors impair synaptic plasticity and cause synaptotoxic effects in mouse hippocampal slices, suggesting potential risks for Alzheimer's disease therapies.

This study identifies CAHSs as membrane protectors in tardigrades during dehydration, showing they dimerize to form a mesh that reinforces intracellular membranes.

This study shows that human neurons lacking APP have developmental and presynaptic deficits that are corrected by cholesterol, suggesting APP's role in maintaining cholesterol homeostasis for brain function.

This study shows graphene nanoflakes manipulate membrane cholesterol, altering cell signaling in fibroblasts and neurons.

The paper uses live cell imaging to show that APP and synaptic membrane cholesterol levels reciprocally modulate at synaptic boutons.

This study shows RNA editing of CAPS1 affects synaptic vesicle organization, release, and retrieval by altering protein function in hippocampal neurons.