Stefan Uderhardt

scXMatch quantifies distribution shifts between single-cell data from different conditions using a non-parametric graph-based test, showing robust performance across gene expression, chromatin accessibility, and morphology data.

The paper introduces MaSkel and napari-MaSkel, tools for fast skeletonization and graph-based feature extraction from segmentation masks, using an optimized Lee94 thinning algorithm.

This study shows glomerular endothelial cell-derived extracellular vesicles cross the basement membrane and regulate podocyte function through miR-mediated gene repression and protease activity.

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

The paper investigates how spatial separation of antigens affects cytotoxicity in CAR-TCR cells by analyzing clonotype dynamics and functional TCR contributions.

This study quantifies morphodynamic features of peritoneal resident tissue macrophages in vivo to distinguish functional states and assess tissue age.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

This paper predicts 5-year progression-free survival in melanoma using spatial proteomics and few-shot learning, achieving over 90% accuracy.

The paper identifies fetal liver macrophage subpopulations and shows their role in regulating granulopoiesis and the HSC niche during embryogenesis.

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.