Carolyn L. Cannon

This study identifies caspase-11 as a driver of macrophage hyperinflammation in Polg-related mitochondrial disease models, linking IFN-I signaling to exacerbated infection outcomes.

This study demonstrates that the peptide-mimetic TM5 effectively kills Pseudomonas aeruginosa in vitro and reduces bacterial load in a mouse model of infection with low toxicity.