Alberto Darszon

This study identifies Na+/H+ exchangers as key regulators of plasma membrane hyperpolarization in mouse sperm, challenging the role of PKA and revealing a novel pathway involving cAMP, calcium, and SLO3 K+ channels.

This study reconstructs fluid flow around a free-swimming human sperm using 3D microscopy and numerical models, revealing counter-rotating vortices in the flow pattern.

The paper introduces MSSR, a super resolution method that improves spatial resolution beyond the diffraction limit and outperforms existing approaches in denoising.

The paper presents a discrete mathematical model of the human sperm acrosome reaction that shows acrosomal pH and biochemical heterogeneity regulate the reaction.

The paper develops a mathematical model to show that variability in ion transporter numbers among mouse sperm regulates the fraction that undergo capacitation.

The paper uses a mathematical model to determine which channels control calcium spikes in sea urchin sperm, concluding that CatSper channels are responsible.