Kristina M. Godek

This study shows that developmental regulation of kinetochore phosphorylation, specifically HEC1 hypophosphorylation in hPSCs, leads to reduced mitotic fidelity, which is improved by differentiation.

The paper shows that aneuploid human pluripotent stem cells are outcompeted by diploid cells through Myc and p53-driven cell competition, preserving genome stability.

This study shows Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progression by regulating kinetochore protein localization and correcting erroneous microtubule attachments.